Development of a universal HFn-mab nanoconjugate for triggering Natural Killer cell-mediated immunotherapy of cancer

AIRC funded grant 2018-2023

Development of a versatile antibody-HFn nanoconjugate able to affect a large spectrum of cancers through the activation of the NK cells-mediated antitumor response and assessment of it as an ADCC promoter.

Advanced Nanotechnology to Assist Keeping the tumor microenvironment Involved in cancer Neutralization (ANAKIN)

AIRC funded grant 2022-2025

Development of cancer cells-derived biomimetic nanoparticles targeted to Cancer-Associated Fibroblasts (CAFs) as gene therapy vectors to overcome the biological barriers to NPs delivery in desmoplastic cancers.

Development of a biotechnological nanoparticle platform for the delivery of antitumor therapies using Patient Derived-Organoid library of Breast Cancer

PRIN project in collaboration with UNIMI, UNITV, UNIBS e CNR

Development of an integrated bionanoparticles (BNP) platform for the efficient and safe drug delivery exploiting biological-derived nanocages consisting of three main classes of BNPs: H-Ferritin (HFn), self-assembled nucleic acid (DNA BNPs) and extracellular vesicles (EV BNPs). The BNP platform will be tested on a panel of 2D cell lines and then in a triple negative breast cancer Patient-Derived Organoid (PDO) system which represent a reliable preclinical disease model alternative to conventional in vivo studies. By exploiting targeted nanodrugs, the use of BNPs could increase antitumor efficacy and decrease chemoresistance.

MORE CARE – Monitoring and Optimization of nanoparticle-mediated thermal ablation tREatments for selective CAncer REmoval

In collaboration with UniParth, UCBM and Kaster Medical Technology

Development of biocompatible metallic nanoparticles (BNPs) useful for thermal ablation treatment enhancing thermal effects and immune response in tumors.

The project consists of:

● Synthetizing BNPs suitable to be locally injected in the tumor

● Performing simulation tests to optimize settings considering patient anatomy of the tumor and its external healthy structures

● Monitoring in real-time the temperature and thermal ablation effects.