Development of a universal HFn-mab nanoconjugate for triggering Natural Killer cell-mediated immunotherapy of cancer AIRC funded grant 2018-2023 Development of a versatile antibody-HFn nanoconjugate able to affect a large spectrum of cancers through the activation of the NK cells-mediated antitumor response and assessment of it as an ADCC promoter. Advanced Nanotechnology to Assist Keeping the tumor microenvironment Involved in cancer …

Take advantage of nanomaterials to properly regulate the inflammatory response. In particular, colloidal nanoparticles are exploited to improve the delivery of a peptide (VIVIT) that inhibits calcineurin/NFAT pathway (Patent WO2014013473-A1). The developed drug delivery systems are investigated for the treatment of several pathological conditions (e.g., transplantation rejection, chronic lymphocytic leukaemia) by targeting specific immune cells.

Synthesis and isolation of biocompatible molecules to produce new final products such as beauty creams and lotions. One of the goals is to substitute microplastics present in the majority of commercial goods with eco-friendly materials. Completed characterizations support all the formulations. Search for novel sustainable materials from marine sources for replacing synthetic substances in cosmetics. PNRR-MUSA (Multilayered urban sustainability action) …

Study of different formulations for the preparation of orally disintegrating tablets (ODT) by using a binder jetting 3D printer and their characterization Synthesis and characterization of polymeric nanoparticles vehiculated in oral dosage forms as pellets, tablets or 3D printing tablets to promote oral administration of biological molecules or poor soluble drugs. Solid formulations for supplements and skin care products for …

Studies of interaction of nanomaterials with biological systems Several scientists have pointed out that lack of knowledge in the interaction of nanomaterials with biological systems can seriously limit nanotechnology potential. Thus, part of our research activity aims to give a contribution to this field by investigating nanoparticles intracellular trafficking, their capability of crossing the biological barriers, nanotoxicology or their potential …